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Protocol - Acute Subjective Response to Substances - Current - Specific - Drugs

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Protocol Name from Source:

Addiction Research Center Inventory (ARCI)

Availability:

Publicly available

Description:

The Addiction Research Center Inventory (ARCI) is a subjective drug effects questionnaire to evaluate whether a respondent is currently affected by or under the influence of a psychologically active drug. The self-reported questionnaire was developed in the early 1960s at the National Institute of Mental Health Addiction Research Center from the use of sentence completion and other association techniques on male subjects under drug and placebo conditions. The full form of ARCI contains 550 true-false items to delineate schizoid and psychopathic characteristics, and shortened versions are widely used for both males and females.

Protocol:

Amphetamine Scale:

1. I feel as if I would be more popular with people right now.

[ ] T

[ ] F

2. I feel a very pleasant emptiness.

[ ] T

[ ] F

3. My thoughts come more easily than usual.

[ ] T

[ ] F

4. I feel less discouraged than usual.

[ ] T

[ ] F

5. I feel more excited than dreamy.

[ ] T

[ ] F

6. Answering these questions is very easy right now.

[ ] T

[ ] F

7. My memory seems sharper to me than usual.

[ ] T

[ ] F

8. I feel as if I could write for hours.

[ ] T

[ ] F

9. I feel very patient.

[ ] T

[ ] F

10. Some parts of my body are tingling.

[ ] T

[ ] F

11. I have a weird feeling.

[ ] T

[ ] F

Morphine-Benzedrine Scale:

12. I feel as though I say things in the easiest possible way right now.

[ ] T

[ ] F

13. Things around me seem more pleasing than usual.

[ ] T

[ ] F

14. I have a pleasant feeling in my stomach.

[ ] T

[ ] F

15. I fear I will lose the contentment that I have now.

[ ] T

[ ] F

16. I feel in complete harmony with the world and those around me.

[ ] T

[ ] F

17. I can completely appreciate what others are saying when I am in this mood.

[ ] T

[ ] F

18. I would be happy all the time if I felt as good as I feel now.

[ ] T

[ ] F

19. I feel so good that I know other people can tell it.

[ ] T

[ ] F

20. I feel as if something pleasant had just happened to me.

[ ] T

[ ] F

21. I would be happy all the time if I felt as I do now.

[ ] T

[ ] F

22. I feel more clear headed than dreamy.

[ ] T

[ ] F

23. I feel as if I would be more popular with people right now.

[ ] T

[ ] F

24. I am in the mood to talk about the feelings I have.

[ ] T

[ ] F

25. I feel a very pleasant emptiness.

[ ] T

[ ] F

26. My thoughts come more easily than usual.

[ ] T

[ ] F

27. I feel less discouraged than usual.

[ ] T

[ ] F

Lysergic Acid Diethylamide (LSD) Scale:

28. I feel drowsy.

[ ] T

[ ] F

29. I would be happy all the time if I felt as I do now.

[ ] T

[ ] F

30. I feel very patient.

[ ] T

[ ] F

31. Some parts of my body are tingling.

[ ] T

[ ] F

32. I have a weird feeling.

[ ] T

[ ] F

33. It seems I am spending longer than I should on each of these questions.

[ ] T

[ ] F

34. My hands feel clumsy.

[ ] T

[ ] F

35. I notice my hand shakes when I write.

[ ] T

[ ] F

36. I have a disturbance in my stomach.

[ ] T

[ ] F

37. I have an increasing awareness of my bodily sensations.

[ ] T

[ ] F

38. I feel anxious and upset.

[ ] T

[ ] F

39. I have an unusual weakness in my muscles.

[ ] T

[ ] F

40. A thrill has gone through me one or more times since I started this test.

[ ] T

[ ] F

41. My movements are free, relaxed, and pleasurable.

[ ] T

[ ] F

Benzedrine Scale:

42. People might say I am a little dull right now.

[ ] T

[ ] F

43. I feel more clear headed than dreamy.

[ ] T

[ ] F

44. My thoughts come more easily than usual.

[ ] T

[ ] F

45. I am in the mood to talk about the feelings I have.

[ ] T

[ ] F

46. Answering these questions is very easy right now.

[ ] T

[ ] F

47. My memory seems sharper to me than usual.

[ ] T

[ ] F

48. I feel as if I could write for hours.

[ ] T

[ ] F

49. Some parts of my body are tingling.

[ ] T

[ ] F

50. My movements seem faster than usual.

[ ] T

[ ] F

51. I have better control over myself than usual.

[ ] T

[ ] F

52. My movements seem slower than usual.

[ ] T

[ ] F

53. I find it hard to keep my mind on a task or job.

[ ] T

[ ] F

54. I don’t feel like reading anything right now.

[ ] T

[ ] F

Pentobarbital-Chlorpromazine-Alcohol Scale:

55. My speech is slurred.

[ ] T

[ ] F

56. I am not as active as usual.

[ ] T

[ ] F

57. I have a feeling of just dragging along rather than coasting.

[ ] T

[ ] F

58. I feel sluggish.

[ ] T

[ ] F

59. My head feels heavy.

[ ] T

[ ] F

60. I feel like avoiding people although I usually do not feel this way.

[ ] T

[ ] F

61. I feel dizzy.

[ ] T

[ ] F

62. It seems harder than usual to move around.

[ ] T

[ ] F

63. I am moody.

[ ] T

[ ] F

64. People might say I am a little dull right now.

[ ] T

[ ] F

65. I feel drowsy.

[ ] T

[ ] F

66. I am full of energy.

[ ] T

[ ] F

67. I feel more clear headed than dreamy.

[ ] T

[ ] F

68. I feel more excited than dreamy.

[ ] T

[ ] F

69. A thrill has gone through me one or more times since I started this test.

[ ] T

[ ] F

Marijuana Scale:

70. Things around me seem more pleasing than usual.

[ ] T

[ ] F

71. I feel as if something pleasant had just happened to me.

[ ] T

[ ] F

72. I have difficulty in remembering.

[ ] T

[ ] F

73. I feel a very pleasant emptiness.

[ ] T

[ ] F

74. My mouth seems very dry.

[ ] T

[ ] F

75. Some parts of my body are tingling.

[ ] T

[ ] F

76. I have a weird feeling.

[ ] T

[ ] F

77. My movements seem slower than usual.

[ ] T

[ ] F

78. I notice that my heart is beating faster.

[ ] T

[ ] F

79. My thoughts seem to come and go.

[ ] T

[ ] F

80. I notice my hands are shaking.

[ ] T

[ ] F

81. I have an increasing awareness of my bodily sensations.

[ ] T

[ ] F

Scoring Procedures and Interpretation

The Addiction Research Center Inventory (ARCI) answer sheet is in true-false format. In scoring all scales, one point is given for each response, which agrees with the scoring direction (Haertzen, 1974a). One point is given for each true response in items 1-21, 23-27, 31-40, 43-51, 55-65, and 70-81. One point is given for each false response in the reverse-scored items 22, 28-30, 41, 42, 52-54, and 66-69. The final score for each scale is the sum of the total true and reverse-scored false responses.

Personnel and Training Required

None

Equipment Needs

None

Requirements

Requirement CategoryRequired
Average time of greater than 15 minutes in an unaffected individualNo
Major equipmentNo
Specialized requirements for biospecimen collectionNo
Specialized trainingNo

Mode of Administration

Self-administered

Life Stage:

Adult, Senior

Specific Instructions:

The Addiction Research Center Inventory (ARCI) is used in laboratory studies to assess the subjective effects of acute doses of drugs of abuse, usually under double-blind, placebo-controlled conditions. The experimenter administers a single dose of a drug or a placebo using an appropriate route (oral, intravenous, intranasal, buccal, inhaled or other). The participant typically completes the ARCI before and again at regular intervals after ingesting active drug or placebo, to characterize the full time course of the drug effect, including the time of onset, time to peak, and return to baseline. The ARCI provides an index of similarity to different classes of drugs (e.g., stimulant, sedative, lysergic acid diethylamide [LSD]-like) and also provides a measure of euphoria induced by several different drugs. The LSD scale is used occasionally as an indicator of dysphoria (negative mood or confusion).

Depending on the purpose of the study, the investigator may include some but not all of these subscales. Note that some items appear on more than one scale. When using multiple scales, as demonstrated by Martin et al. (1971), each item should appear only once but should be scored in all appropriate scales, and the items (some of which are reverse-scored) should be intermixed across scales.

The Substance Abuse and Addiction Working Group acknowledges that the following questions may gather sensitive information relating to the use of substances and/or illegal conduct. If the information is released, it might be damaging to an individual’s employability, lead to social stigmatization, or lead to other consequences.

Most researchers assure confidentiality as part of their informed consent process, as required by their institutional review boards. Further assurance of confidentiality may be obtained by applying to the National Institutes of Health (NIH) for a Certificate of Confidentiality, which helps researchers protect the privacy of human research participants. The procedures for the Certificate of Confidentiality can be found at the Grants Policy website of NIH: http://grants1.nih.gov/grants/policy/coc/index.htm.

Research Domain Information

Release Date:

February 24, 2012

Definition

Instruments used separately to assess current acute subjective responses to substances that the respondent has recently ingested or used.

Purpose

This measure is to assess a respondent’s feelings after recently smoking cigarettes, ingesting alcohol, or using drugs. The protocol is used to obtain subjective responses to the tobacco, alcohol, or drug administered. The Working Group recommends that investigators use the primary protocol to obtain general information on a variety of substances. The secondary protocols can then be used to obtain detailed information on a specific substance.

Selection Rationale

The full form of the Addiction Research Center Inventory (ARCI) effectively differentiates various subjective effects of drugs and detects similarities and differences of naturally occurring and experimentally induced behavioral abnormalities. However, it is rarely administered in its full form because of its length. An abbreviated form of the ARCI can be administered quickly and provides a good index of the quality, magnitude, and time course of a drug’s effects. A 49-item version is composed of five different scales (Amphetamine, Morphine-Benzedrine, Lysergic Acid Diethylamide (LSD), Benzedrine, and Pentobarbital-Chlorpromazine-Alcohol) for various classes of drug effects (Martin et al., 1971). A 53-item version also includes a sixth scale, measuring marijuana effects (Chait et al., 1994). This was selected due to its low burden.

Language

English, French, German, Spanish, Swedish

Standards

StandardNameIDSource
Common Data Elements (CDE)Addiction Research Center Inventory (ARCI) Assessment Description Text3332435CDE Browser

Process and Review

The [link[phenx.org/Default.aspx?tabid=1041|Expert Review Panel #3]] (ERP 3) reviewed the measures in Alcohol, Tobacco and Other Substances, and Substance Abuse and Addiction domains.

Guidance from ERP 3 includes:

• No significant changes to measure

Back-compatible: NA no changes to Data Dictionary

Source

Amphetamine, Morphine-Benzedrine, Lysergic Acid (LSD), Benzedrine, and Pentobarbital-Chlorpromazine-Alcohol Scales

Martin, W. R., Sloan, J. W., Sapira, J. D., & Jasinski, D. R. (1971). Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clinical Pharmacology and Therapeutics, 12(2), 245-258.

Marijuana Scale

Chait, L. D., & Perry, J. L. (1994). Acute and residual effects of alcohol and marijuana, alone and in combination, on mood and performance. Psychopharmacology, 115(3), 340-349.

General References

Haertzen, C. A. (1965). Addiction Research Center Inventory (ARCI): Development of a general drug estimation scale. Journal of Nervous and Mental Disease, 141, 300-307.

Haertzen, C. A., & Hickey, J. E. (1987). Addiction Research Center Inventory (ARCI): Measurement of euphoria and other drug effects. In M. A. Bozarth (Ed.), Methods of assessing the reinforcing properties of abused drugs (pp. 489-524). New York: Springer-Verlag.

Haertzen, C. A., Hill, H. E., & Belleville, R. E. (1963). Development of the Addiction Research Center Inventory (ARCI): Selection of items that are sensitive to the effects of various drugs. Psychopharmacologia, 4, 155-166.

Hill, H. E., Haertzen, C. A., Wolbach, A. B., Jr., & Miner, E. J. (1963). The Addiction Research Center Inventory: Standarization of scales which evaluate subjective effects of morphine, Amphetamine, pentobarbital, alcohol, LSD-25, pyrahexyl and chlorpromazine. Psychopharmacologia, 4, 167-183.

Kirk, J. M., Doty, P., & de Wit, H. (1998). Effects of expectancies on subjective responses to oral ∆9-tetrahydrocannabinol. Pharmacology, Biochemistry, and Behavior, 59, 287-293.

Preston, K. L., & Jasinski, D. R. (1991). Abuse liability studies of opioid agonist-antagonists in humans. Drug and Alcohol Dependence, 28(1), 49-82.

Wachtel, S. R., ElSohly, M. A., Ross, S. A., Ambre, J., & de Wit, H. (2002). Comparison of the subjective effects of ∆9-tetrahydrocannabinol and marijuana in humans. Psychopharmacology, 161, 331-339.

Protocol ID:

520101

Variables:

Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
PX520101_More_Popular_With_People_AmphetaminePX520101010000I feel as if I would be more popular with people right now.4N/A
PX520101_Pleasant_Emptiness_AmphetaminePX520101020000I feel a very pleasant emptiness.4N/A
PX520101_Thoughts_Come_More_Easily_AmphetaminePX520101030000My thoughts come more easily than usual.4N/A
PX520101_Feel_Less_Discouraged_AmphetaminePX520101040000I feel less discouraged than usual.4N/A
PX520101_More_Excited_Than_Dreamy_AmphetaminePX520101050000I feel more excited than dreamy.4N/A
PX520101_Answering_Questions_Is_Easy_AmphetaminePX520101060000Answering these questions is very easy right now.4N/A
PX520101_My_Memory_Seems_Sharper_AmphetaminePX520101070000My memory seems sharper to me than usual.4N/A
PX520101_Write_For_Hours_AmphetaminePX520101080000I feel as if I could write for hours.4N/A
PX520101_Feel_Very_Patient_AmphetaminePX520101090000I feel very patient.4N/A
PX520101_Body_Parts_Tingling_AmphetaminePX520101100000Some parts of my body are tingling.4N/A
PX520101_Weird_Feeling_AmphetaminePX520101110000I have a weird feeling.4N/A
PX520101_Say_Things_Easiest_MorphinePX520101120000I feel as though I say things in the easiest possible way right now.4N/A
PX520101_Things_Seem_More_Pleasing_MorphinePX520101130000Things around me seem more pleasing than usual.4N/A
PX520101_Pleasant_Feeling_In_Stomach_MorphinePX520101140000I have a pleasant feeling in my stomach.4N/A
PX520101_Fear_Lose_Contentment_MorphinePX520101150000I fear I will lose the contentment that I have now.4N/A
PX520101_Feel_In_Complete_Harmony_MorphinePX520101160000I feel in complete harmony with the world and those around me.4N/A
PX520101_Appreciate_What_Others_Say_MorphinePX520101170000I can completely appreciate what others are saying when I am in this mood.4N/A
PX520101_Happy_All_The_Time_MorphinePX520101180000I would be happy all the time if I felt as good as I feel now.4N/A
PX520101_Other_People_Can_Tell_MorphinePX520101190000I feel so good that I know other people can tell it.4N/A
PX520101_Happy_All_The_Time2_MorphinePX520101210000I would be happy all the time if I felt as I do now.4N/A
PX520101_More_Clear_Headed_Than_Dreamy_MorphinePX520101220000I feel more clear headed than dreamy.4N/A
PX520101_More_Popular_With_People_MorphinePX520101230000I feel as if I would be more popular with people right now.4N/A
PX520101_Talk_About_Feelings_MorphinePX520101240000I am in the mood to talk about the feelings I have.4N/A
PX520101_Pleasant_Emptiness_MorphinePX520101250000I feel a very pleasant emptiness.4N/A
PX520101_Thoughts_Come_More_Easily_MorphinePX520101260000My thoughts come more easily than usual.4N/A
PX520101_Less_Discouraged_MorphinePX520101270000I feel less discouraged than usual.4N/A
PX520101_Feel_Drowsy_LSDPX520101280000I feel drowsy.4N/A
PX520101_Happy_All_The_Time_LSDPX520101290000I would be happy all the time if I felt as I do now.4N/A
PX520101_Feel_Very_Patient_LSDPX520101300000I feel very patient.4N/A
PX520101_Body_Parts_Tingling_LSDPX520101310000Some parts of my body are tingling.4N/A
PX520101_Weird_Feeling_LSDPX520101320000I have a weird feeling.4N/A
PX520101_Spending_Longer_On_Questions_LSDPX520101330000It seems I am spending longer than I should on each of these questions.4N/A
PX520101_My_Hands_Feel_Clumsy_LSDPX520101340000My hands feel clumsy.4N/A
PX520101_My_Hand_Shakes_LSDPX520101350000I notice my hand shakes when I write.4N/A
PX520101_Stomach_Disturbance_LSDPX520101360000I have a disturbance in my stomach.4N/A
PX520101_Awareness_Of_Bodily_Sensations_LSDPX520101370000I have an increasing awareness of my bodily sensations.4N/A
PX520101_Anxious_And_Upset_LSDPX520101380000I feel anxious and upset.4N/A
PX520101_Unusual_Muscle_Weakness_LSDPX520101390000I have an unusual weakness in my muscles.4N/A
PX520101_Thrill_Gone_Through_Me_LSDPX520101400000A thrill has gone through me one or more times since I started this test.4N/A
PX520101_Movements_Free_Relaxed_Pleasurable_LSDPX520101410000My movements are free, relaxed, and pleasurable.4N/A
PX520101_Little_Dull_Right_Now_BenzedrinePX520101420000People might say I am a little dull right now.4N/A
PX520101_More_Clear_Headed_BenzedrinePX520101430000I feel more clear headed than dreamy.4N/A
PX520101_Thoughts_Come_More_Easily_BenzedrinePX520101440000My thoughts come more easily than usual.4N/A
PX520101_Talk_About_Feelings_BenzedrinePX520101450000I am in the mood to talk about the feelings I have.4N/A
PX520101_Answering_Questions_Is_Easy_BenzedrinePX520101460000Answering these questions is very easy right now.4N/A
PX520101_Memory_Seems_Sharpe_BenzedrinePX520101470000My memory seems sharper to me than usual.4N/A
PX520101_Write_For_Hours_BenzedrinePX520101480000I feel as if I could write for hours.4N/A
PX520101_Body_Parts_Tingling_BenzedrinePX520101490000Some parts of my body are tingling.4N/A
PX520101_Movements_Faster_Than_Usual_BenzedrinePX520101500000My movements seem faster than usual.4N/A
PX520101_Better_Control_Over_Myself_BenzedrinePX520101510000I have better control over myself than usual.4N/A
PX520101_Movements_Seem_Slower_BenzedrinePX520101520000My movements seem slower than usual.4N/A
PX520101_Hard_To_Keep_Mind_BenzedrinePX520101530000I find it hard to keep my mind on a task or job.4N/A
PX520101_Don¿¿¿t_Feel_Like_Reading_BenzedrinePX520101540000I don¿¿¿t feel like reading anything right now.4N/A
PX520101_My_Speech_Is_Slurred_Pentobarbital/Chlorpromazine/AlcoholPX520101550000My speech is slurred.4N/A
PX520101_Not_As_Active_Pentobarbital/Chlorpromazine/AlcoholPX520101560000I am not as active as usual.4N/A
PX520101_Dragging_Along_Pentobarbital/Chlorpromazine/AlcoholPX520101570000I have a feeling of just dragging along rather than coasting.4N/A
PX520101_I_Feel_Sluggish_Pentobarbital/Chlorpromazine/AlcoholPX520101580000I feel sluggish.4N/A
PX520101_My_Head_Feels_Heavy_Pentobarbital/Chlorpromazine/AlcoholPX520101590000My head feels heavy.4N/A
PX520101_Feel_Like_Avoiding_People_Pentobarbital/Chlorpromazine/AlcoholPX520101600000I feel like avoiding people although I usually do not feel this way.4N/A
PX520101_Feel_Something_Pleasant_Happened_MorphinePX520101200000I feel as if something pleasant had just happened to me.4N/A
PX520101_I_Feel_Dizzy_Pentobarbital/Chlorpromazine/AlcoholPX520101610000I feel dizzy.4N/A
PX520101_Harder_Move_Around_Pentobarbital/Chlorpromazine/AlcoholPX520101620000It seems harder than usual to move around.4N/A
PX520101_I_Am_Moody_Pentobarbital/Chlorpromazine/AlcoholPX520101630000I am moody.4N/A
PX520101_Dull_Right_Now_Pentobarbital/Chlorpromazine/AlcoholPX520101640000People might say I am a little dull right now.4N/A
PX520101_I_Feel_Drowsy_Pentobarbital/Chlorpromazine/AlcoholPX520101650000I feel drowsy.4N/A
PX520101_Full_Of_Energy_Pentobarbital/Chlorpromazine/AlcoholPX520101660000I am full of energy.4N/A
PX520101_More_Clear_Headed_Pentobarbital/Chlorpromazine/AlcoholPX520101670000I feel more clear headed than dreamy.4N/A
PX520101_More_Excited_Pentobarbital/Chlorpromazine/AlcoholPX520101680000I feel more excited than dreamy.4N/A
PX520101_Thrill_Gone_Through_Me_Pentobarbital/Chlorpromazine/AlcoholPX520101690000A thrill has gone through me one or more times since I started this test.4N/A
PX520101_More_Pleasing_Than_Usual_MarijuanaPX520101700000Things around me seem more pleasing than usual.4N/A
PX520101_Something_Pleasant_Happened_MarijuanaPX520101710000I feel as if something pleasant had just happened to me.4N/A
PX520101_Pleasant_Emptiness_MarijuanaPX520101730000I feel a very pleasant emptiness.4N/A
PX520101_Mouth_Seems_Dry_MarijuanaPX520101740000My mouth seems very dry.4N/A
PX520101_Body_Parts_Tingling_MarijuanaPX520101750000Some parts of my body are tingling.4N/A
PX520101_Weird_Feeling_MarijuanaPX520101760000I have a weird feeling.4N/A
PX520101_Movements_Seem_Slower_MarijuanaPX520101770000My movements seem slower than usual.4N/A
PX520101_Heart_Beating_Faster_MarijuanaPX520101780000I notice that my heart is beating faster.4N/A
PX520101_Thoughts_Come_And_Go_MarijuanaPX520101790000My thoughts seem to come and go.4N/A
PX520101_Hands_Are_Shaking_MarijuanaPX520101800000I notice my hands are shaking.4N/A
PX520101_Increasing_Awareness_Of_Sensations_MarijuanaPX520101810000I have an increasing awareness of my bodily sensations.4N/A
PX520101_Difficulty_Remembering_MarijuanaPX520101720000I have difficulty in remembering.4N/A