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Protocol - Family History of Substance Use Problems - Alcohol

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Protocol Name from Source:

Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV)

Availability:

Publicly available

Description:

The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV) is a fully structured diagnostic interview designed to assess alcohol, drug, and mental disorders according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), diagnostic criteria in both clinical and general populations. Section 2D of AUDADIS-IV assesses a respondent’s family history of drinking problems or alcoholism (generally defined).

Protocol:

Now I would like to ask you some questions about whether any of your relatives, regardless of whether or not they are now living, have EVER been alcoholics or problem drinkers. By alcoholic or problem drinker, I mean a person who has physical or emotional problems because of drinking (PAUSE); problems with a spouse/partner, family, or friends because of drinking (PAUSE); problems at work or school because of drinking (PAUSE); problems with the police because of drinking-like drunk driving (PAUSE) or a person who seems to spend a lot of time drinking or being hung over. (Repeat definition frequently.)

1. Has/Was your blood or natural father been an alcoholic or problem drinker at ANY time in his life?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

2. Has/Was your blood or natural mother been an alcoholic or problem drinker at ANY time in her life?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

3a. How many full brothers have you had who lived to be at least 10 years old, including those who are still living? By full brothers, I mean brothers who have the same natural mother AND the same natural father as you do.

___Number

0 [ ] None

Don’t Know/Refused

If Question 3a is None, Don’t Know, or Refused, then skip to Question 4a.

If Question 3a is 1, then respondent is asked Question 3b.

If Question 3a is >1, then respondent is asked Question 3c.

3b. Was your full brother an alcoholic or problem drinker at ANY time in his life?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

3c. How many of your full brothers are now, or were in the past, alcoholics or problem drinkers?

___Number

Don’t Know/Refused

4a. How many full sisters have you had who lived to be at least 10 years old, including those who are still living? By full sisters, I mean sisters who have the same natural mother AND the same natural father as you do.

___Number

0 [ ] None

Don’t Know/Refused

If Question 4a is None, Don’t Know, or Refused, then skip to Question 5a.

If Question 4a is 1, then respondent is asked Question 4b.

If Question 4a is >1, then respondent is asked Question 4c.

4b. Was your full sister an alcoholic or problem drinker at ANY time in her life?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

4c. How many of your full sisters are now, or were in the past, alcoholics or problem drinkers?

___Number

Don’t Know/Refused

5a. How many natural sons have you had who lived to be at least 10 years old, including those who are still living? By natural, I mean those who you (biologically fathered/gave birth to.)

___Number

0 [ ] None

Don’t Know/Refused

If Question 5a is None, Don’t Know, or Refused, then skip to Question 6a.

If Question 5a is 1, then respondent is asked Question 5b.

If Question 5a is >1, then respondent is asked Question 5c.

5b. Was your natural son an alcoholic or problem drinker at ANY time in his life?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

5c. How many of your natural sons are now, or were in the past, alcoholics or problem drinkers?

___Number

Don’t Know/Refused

6a. How many natural daughters have you had who lived to be at least 10 years old, including those who are still living? By natural, I mean those who you (biologically fathered/gave birth to.)

___Number

0 [ ] None

Don’t Know/Refused

If Question 6a is None, Don’t Know, or Refused, then skip to Question 7a.

If Question 6a is 1, then respondent is asked Question 6b.

If Question 6a is >1, then respondent is asked Question 6c.

6b. Was your natural daughter an alcoholic or problem drinker at ANY time in her life?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

6c. How many of your natural daughters are now, or were in the past, alcoholics or problem drinkers?

___Number

Don’t Know/Refused

7a. How many full brothers did your natural father have who lived to be at least 10 years old, including those who are still alive? By full brothers, I mean those who had the SAME TWO natural or blood parents as your father.

___Number

0 [ ] None

Don’t Know/Refused

If Question 7a is None, Don’t Know, or Refused, then skip to Question 8a.

If Question 7a is 1, then respondent is asked Question 7b.

If Question 7a is >1, then respondent is asked Question 7c.

7b. Was your natural father’s full brother an alcoholic or problem drinker at ANY time in his life?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

7c. How many of your natural father’s full brothers are now, or were in the past, alcoholics or problem drinkers?

___Number

Don’t Know/Refused

8a. How many full sisters did your natural father have who lived to be at least 10 years old, including those who are still living? By full sisters, I mean those who had the SAME TWO natural or blood parents as your father.

___Number

0 [ ] None

Don’t Know/Refused

If Question 8a is None, Don’t Know, or Refused, then skip to Question 9a.

If Question 8a is 1, then respondent is asked Question 8b.

If Question 8a is >1, then respondent is asked Question 8c.

8b. Was your natural father’s full sister an alcoholic or problem drinker at ANY time in her life?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

8c. How many of your natural father’s full sisters are now, or were in the past, alcoholics or problem drinkers?

___Number

Don’t Know/Refused

9a. How many full brothers did your natural mother have who lived to be at least 10 years old, including those who are still living? By full brothers, I mean those who had the SAME TWO natural or blood parents as your mother.

___Number

0 [ ] None

Don’t Know/Refused

If Question 9a is None, Don’t Know, or Refused, then skip to Question 10a.

If Question 9a is 1, then respondent is asked Question 9b.

If Question 9a is >1, then respondent is asked Question 9c.

9b. Was your natural mother’s full brother an alcoholic or problem drinker at ANY time in his life?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

9c. How many of your natural mother’s full brothers are now, or were in the past, alcoholics or problem drinkers?

___Number

Don’t Know/Refused

10a. How many full sisters did your natural mother have who lived to be at least 10 years old, including those who are still alive? By full sisters, I mean those who had the SAME TWO natural or blood parents as your mother.

___Number

0 [ ] None

Don’t Know/Refused

If Question 10a is None, Don’t Know, or Refused, then skip to Question 11.

If Question 10a is 1, then respondent is asked Question 10b.

If Question 10a is >1, then respondent is asked Question 10b.

10b. Was your natural mother’s full sister an alcoholic or problem drinker at ANY time in her life?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

10c. How many of your natural mother’s full brothers are now, or were in the past, alcoholics or problem drinkers?

___Number

Don’t Know/Refused

11. Was your natural grandfather on your father’s side an alcoholic or problem drinker at ANY time in his life? By natural grandfather on your father’s side, I mean your father’s natural or blood father.

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

12. Was your natural grandmother on your father’s side an alcoholic or problem drinker at ANY time in her life? By natural grandmother on your father’s side, I mean your father’s natural or blood mother.

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

13a. Was your natural grandfather on your mother’s side an alcoholic or problem drinker at ANY time in his life? By natural grandfather on your mother’s side, I mean your mother’s natural or blood father.

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

13b. Was your natural grandmother on your mother’s side an alcoholic or problem drinker at ANY time in her life? By natural grandmother on your mother’s side, I mean your mother’s natural or blood mother.

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

If respondent has never been married, then skip to Question 17.

Otherwise, respondent is asked Question 14

14. Were you EVER married to an alcoholic or problem drinker?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

If Question 14 is No, Don’t Know, or Refused, then skip to Question 17.

If Question 14 is Yes, continue with Question 15.

15. Is that your current (husband/wife)?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

If Question 15 is No, Don’t Know, or Refused, then skip to Question 17.

16. Would you say that (he/she) is an alcoholic or problem drinker at this time?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

17. Did you EVER live with someone as if you were married?

Reiterate that this person is not a spouse.

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

If Question 17 is No, Don’t Know, or Refused, then end section.

If Question 17 is Yes, then respondent is asked Questions 18-19.

18. Did you EVER live as if married with someone who was an alcoholic or problem drinker?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

19. Is that the person you live with now?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

If Question 19 is No, Don’t Know, or Refused, then end section.

20. Would you say that (he/she) is an alcoholic or problem drinker at this time?

1 [ ] Yes

2 [ ] No

Don’t Know/Refused

Personnel and Training Required

The interviewer must be trained to conduct personal interviews with individuals from the general population. The interviewer must be trained and found to be competent (i.e., tested by an expert) in the completion of personal interviews. The interviewer should be trained to prompt respondents further if a "don’t know" response is provided.

Equipment Needs

While the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV) was developed for administration by computer, the literature suggests that these questions can be administered in a noncomputerized format. Hasin et al. (1997) and Grant et al. (1995) used AUDADIS-IV in paper-and-pencil format, while Grant et al. (2003) obtained data with the computerized format. If the questions are administered via paper and pencil, it is essential that the proper skip pattern is followed.

Requirements

Requirement CategoryRequired
Average time of greater than 15 minutes in an unaffected individualNo
Major equipmentNo
Specialized requirements for biospecimen collectionNo
Specialized trainingNo

Mode of Administration

Self-administered

Life Stage:

Adult, Senior

Specific Instructions:

This measure was previously included in the Alcohol, Tobacco, and Other Substances (ATOS) Supplemental Information as "Alcohol - Family history of alcohol abuse" and was promoted to the Toolkit on February 24, 2012 by the Working Group on Assessment of Substance Use and Substance Use Disorders.

The Substance Abuse and Addiction Working Group acknowledges that the following questions may gather sensitive information relating to the use of substances and/or illegal conduct. If the information is released, it might be damaging to an individual’s employability, lead to social stigmatization, or lead to other consequences.

Most researchers assure confidentiality as part of their informed consent process, as required by their institutional review boards. Further assurance of confidentiality may be obtained by applying to the National Institutes of Health (NIH) for a Certificate of Confidentiality, which helps researchers protect the privacy of human research participants. The procedures for the Certificate of Confidentiality can be found at the Grants Policy website of NIH: http://grants1.nih.gov/grants/policy/coc/index.htm.

Research Domain Information

Release Date:

November 21, 2016

Definition

Instruments used separately to obtain family history of substance use problems including tobacco, alcohol, and other drugs.

Purpose

The purpose of this measure is to obtain a family history of substance use problems by asking the respondent whether or not any first- or second-degree biological relatives or spouses/partners have a history of problems with tobacco, alcohol, and other drugs.

Selection Rationale

The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV) was chosen because it has been used in a large epidemiologic study, the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), containing adults with a wide age range and different ethnicities. The questions from this protocol have been validated, and they are low burden. While originally developed as interviewer-administered, AUDADIS has been validated in several modes of administration.

Unlike other validated instruments that probe only first-degree relatives, AUDADIS-IV captures first- and second-degree relatives as well as spouses/partners.

Language

English

Standards

StandardNameIDSource
Common Data Elements (CDE)Family Medical History Alcohol Use History2958514CDE Browser

Process and Review

The [link[phenx.org/node/101|Expert Review Panel #3]] (ERP 3) reviewed the measures in Alcohol, Tobacco and Other Substances, and Substance Abuse and Addiction domains.

Guidance from ERP 3 includes:

• No significant changes to measure

Back-compatible: NA no changes to Data Dictionary

Source

Grant, B. F., Dawson, D. A., Stinson, F. S., Chou, P. S., Kay, W., & Pickering, R. (2003). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample. Drug and Alcohol Dependence, 71(1), 7-16.

National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Epidemiologic Survey on Alcohol and Related Conditions, Wave 1 (NESARC-WAVE 1). Alcohol Use Disorder and Associated Disabilities Interview Schedule - Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition Version (AUDADIS-IV). Section 2D. Questions 1-13b.

General References

Grant, B. F., Dawson, D. A., & Hasin, D. S. (2001). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version. Bethesda, MD: National Institute on Alcohol Abuse and Alcoholism.

Grant, B. F., Dawson, D. A., Stinson, F. S., Chou, P. S., Kay, W., & Pickering, R. (2003). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample. Drug and Alcohol Dependence, 71(1), 7-16.

Grant, B. F., Harford, T. C., Dawson, D. A., Chou, P. S., & Pickering, R. P. (1995). The Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): Reliability of alcohol and drug modules in a general population sample. Drug and Alcohol Dependence, 39(1), 37-44.

Hasin, D., Carpenter, K. M., McCloud, S., Smith, M., & Grant, B. F. (1997). The Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): Reliability of alcohol and drug modules in a clinical sample. Drug and Alcohol Dependence, 44(2-3):133-141.

Protocol ID:

510101

Variables:

Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
PX510101_Father_Alcoholic_Problem_DrinkerPX510101010000Has/Was your blood or natural father been an alcoholic or problem drinker at ANY time in his life?4N/A
PX510101_Mother_Alcoholic_Problem_DrinkerPX510101020000Has/Was your blood or natural mother been an alcoholic or problem drinker at ANY time in her life?4N/A
PX510101_Number_Full_BrothersPX510101030100How many full brothers have you had who lived to be at least 10 years old, including those who are still living? By full brothers, I mean brothers who have the same natural mother AND the same natural father as you do.4N/A
PX510101_Brother_Alcoholic_Problem_DrinkerPX510101030200Was your full brother an alcoholic or problem drinker at ANY time in his life?4N/A
PX510101_Number_Brothers_Alcoholic_Problem_DrinkerPX510101030300How many of your full brothers are now, or were in the past, alcoholics or problem drinkers?4N/A
PX510101_Number_Full_SistersPX510101040100How many full sisters have you had who lived to be at least 10 years old, including those who are still living? By full sisters, I mean sisters who have the same natural mother AND the same natural father as you do.4N/A
PX510101_Sister_Alcoholic_Problem_DrinkerPX510101040200Was your full sister an alcoholic or problem drinker at ANY time in her life?4N/A
PX510101_Number_Natural_SonsPX510101050100How many natural sons have you had who lived to be at least 10 years old, including those who are still living? By natural, I mean those who you (biologically fathered/gave birth to.)4N/A
PX510101_Son_Alcoholic_Problem_DrinkerPX510101050200Was your natural son an alcoholic or problem drinker at ANY time in his life?4N/A
PX510101_Number_Sons_Alcoholic_Problem_DrinkerPX510101050300How many of your natural sons are now, or were in the past, alcoholics or problem drinkers?4N/A
PX510101_Number_Natural_DaughtersPX510101060100How many natural daughters have you had who lived to be at least 10 years old, including those who are still living? By natural, I mean those who you (biologically fathered/gave birth to.)4N/A
PX510101_Daughter_Alcoholic_Problem_DrinkerPX510101060200Was your natural daughter an alcoholic or problem drinker at ANY time in her life?4N/A
PX510101_Number_Daughters_Alcoholic_Problem_DrinkerPX510101060300How many of your natural daughters are now, or were in the past, alcoholics or problem drinkers?4N/A
PX510101_Number_Natural_Paternal_UnclesPX510101070100How many full brothers did your natural father have who lived to be at least 10¿¿years old, including those who are still alive? By full brothers, I mean those who had the SAME TWO natural or blood parents as your father.4N/A
PX510101_Paternal_Uncle_Alcoholic_Problem_DrinkerPX510101070200Was your natural father¿¿¿s full brother an alcoholic or problem drinker at ANY time in his life?4N/A
PX510101_Number_Sisters_Alcoholic_Problem_DrinkerPX510101040300How many of your full sisters are now, or were in the past, alcoholics or problem drinkers?4N/A
PX510101_Number_Paternal_Uncles_AlcoholicPX510101070300How many of your natural father¿¿¿s full brothers are now, or were in the past, alcoholics or problem drinkers?4N/A
PX510101_Number_Natural_Paternal_AuntsPX510101080100How many full sisters did your natural father have who lived to be at least 10 years old, including those who are still living? By full sisters, I mean those who had the SAME TWO natural or blood parents as your father.4N/A
PX510101_Paternal_Aunt_Alcoholic_Problem_DrinkerPX510101080200Was your natural father¿¿¿s full sister an alcoholic or problem drinker at ANY time in her life?4N/A
PX510101_Number_Paternal_Aunts_AlcoholicPX510101080300How many of your natural father¿¿¿s full sisters are now, or were in the past, alcoholics or problem drinkers?4N/A
PX510101_Number_Natural_Maternal_UnclesPX510101090100How many full brothers did your natural mother have who lived to be at least 10¿¿years old, including those who are still living? By full brothers, I mean those who had the SAME TWO natural or blood parents as your mother.4N/A
PX510101_Maternal_Uncle_Alcoholic_Problem_DrinkerPX510101090200Was your natural mother¿¿¿s full brother an alcoholic or problem drinker at ANY time in his life?4N/A
PX510101_Number_Maternal_Uncles_AlcoholicPX510101090300How many of your natural mother¿¿¿s full brothers are now, or were in the past, alcoholics or problem drinkers?4N/A
PX510101_Number_Natural_Maternal_AuntsPX510101100100How many full sisters did your natural mother have who lived to be at least 10¿¿years old, including those who are still alive? By full sisters, I mean those who had the SAME TWO natural or blood parents as your mother.4N/A
PX510101_Maternal_Aunt_Alcoholic_Problem_DrinkerPX510101100200Was your natural mother¿¿¿s full sister an alcoholic or problem drinker at ANY time in her life?4N/A
PX510101_Number_Maternal_Aunts_AlcoholicPX510101100300How many of your natural mother¿¿¿s full brothers are now, or were in the past, alcoholics or problem drinkers?4N/A
PX510101_Paternal_Grandfather_AlcoholicPX510101110000Was your natural grandfather on your father¿¿¿s side an alcoholic or problem drinker at ANY time in his life? By natural grandfather on your father¿¿¿s side, I mean your father¿¿¿s natural or blood father.4N/A
PX510101_Paternal_Grandmother_AlcoholicPX510101120000Was your natural grandmother on your father¿¿¿s side an alcoholic or problem drinker at ANY time in her life? By natural grandmother on your father¿¿¿s side, I mean your father¿¿¿s natural or blood mother.4N/A
PX510101_Maternal_Grandfather_AlcoholicPX510101130100Was your natural grandfather on your mother¿¿¿s side an alcoholic or problem drinker at ANY time in his life? By natural grandfather on your mother¿¿¿s side, I mean your mother¿¿¿s natural or blood father.4N/A
PX510101_Maternal_Grandmother_AlcoholicPX510101130200Was your natural grandmother on your mother¿¿¿s side an alcoholic or problem drinker at ANY time in her life? By natural grandmother on your mother¿¿¿s side, I mean your mother¿¿¿s natural or blood mother.4N/A
PX510101_Married_To_AlcoholicPX510101140000Were you EVER married to an alcoholic or problem drinker?4N/A
PX510101_Current_Spouse_AlcoholicPX510101150000Is that your current (husband/wife)?4N/A
PX510101_Current_Spouse_Alcoholic_NowPX510101160000Would you say that (he/she) is an alcoholic or problem drinker at this time?4N/A
PX510101_Live_With_SomeonePX510101170000Did you EVER live with someone as if you were married?4N/A
PX510101_Live_With_Someone_AlcoholicPX510101180000Did you EVER live as if married with someone who was an alcoholic or problem drinker?4N/A
PX510101_Live_With_Someone_Now_AlcoholicPX510101190000Is that the person you live with now?4N/A
PX510101_Live_With_Someone_Alcoholic_CurrentlyPX510101200000Would you say that (he/she) is an alcoholic or problem drinker at this time?4N/A