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Protocol - Cognitive Changes

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Protocol Name from Source:

Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)

Availability:

Publicly available

Description:

The informant (e.g., caregiver) is asked a series of questions to ascertain changes in the subject's cognition over the past two years. The informant indicates whether the subject's cognition in relation to various situations has improved, stayed the same, or gotten worse. These questions are from the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE).

Protocol:

Now we want you to remember what R's FIRST NAME was like two years ago and to compare it with what [he/she] is like now. Two years ago was in {CURRENT INTERVIEW YEAR - 2}. I will read situations where R's FIRST NAME has to use [his/her] memory or intelligence and we would like you to indicate whether this has improved, stayed the same, or gotten worse in that situation over the past two years.

Note the importance of comparing [his/her] present performance with two years ago. So if two years ago R's FIRST NAME always forgot where [he/she] had left things, and [he/she] still does, then this would be considered "not much change."

Now we want you to remember what R's FIRST NAME was like [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR /two years ago] and to compare it with what [he/she] was like toward the end of [his/her] life, but leaving out the last month or so of [his/her] life. I will read situations where R's FIRST NAME had to use [his/her] memory or intelligence and we would like you to indicate whether this had improved, stayed the same, or gotten worse in that situation over that time period.

Note the importance of comparing [his/her] performance toward the end of [his/her] life with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago]. So if two years ago R's FIRST NAME always forgot where [he/she] had left things, and [he/she] still did, then this would be considered "not much change."

1. Compared with two years ago, how is R's FIRST NAME at:

Remembering things about family and friends, such as occupations, birthdays, and addresses.

Has this improved, not much changed, or gotten worse?

Compared with [when we interviewed [him/her] in R's LAST IW MONTH, YEAR/two years ago], how was R's FIRST NAME at:

Remembering things about family and friends, such as occupations, birthdays, and addresses.

Had this improved, not much changed, or gotten worse?

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q4

[ ] 3 GOTTEN WORSE - GO TO Q3

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q4

[ ] 8 DK - GO TO Q4

[ ] 9 RF - GO TO Q4

2. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED - GO TO Q4

[ ] 2 A BIT IMPROVED - GO TO Q4

[ ] 8 DK - GO TO Q4

[ ] 9 RF - GO TO Q4

3. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

4. Compared with two years ago, how is R's FIRST NAME at:

Remembering things that have happened recently?

(Has this improved, not much changed, or gotten worse?)

Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:

Remembering things that had happened recently?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q7

[ ] 3 GOTTEN WORSE- GO TO Q6

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q7

[ ] 8 DK - GO TO Q7

[ ] 9 RF - GO TO Q7

5. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q7

6. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

7. (Compared with two years ago, how is R's FIRST NAME at:)

Recalling conversations a few days later?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Recalling conversations a few days later?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q10

[ ] 3 GOTTEN WORSE - GO TO Q9

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q10

[ ] 8 DK - GO TO Q10

[ ] 9 RF - GO TO Q10

8. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q10

9. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

10. (Compared with two years ago, how is R's FIRST NAME at:)

Remembering [his/her] address and telephone number?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Remembering [his/her] address and telephone number?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q13

[ ] 3 GOTTEN WORSE- GO TO Q12

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q13

[ ] 8 DK - GO TO Q13

[ ] 9 RF - GO TO Q13

11. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q13

12. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

13. (Compared with two years ago, how is R's FIRST NAME at:)

Remembering what day and month it is?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Remembering what day and month it was?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q16

[ ] 3 GOTTEN WORSE - GO TO Q15

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q16

[ ] 8 DK - GO TO Q16

[ ] 9 RF - GO TO Q16

14. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q16

15. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

16. (Compared with two years ago, how is R's FIRST NAME at:)

Remembering where things are usually kept?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST NTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Remembering where things were usually kept?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q19

[ ] 3 GOTTEN WORSE - GO TO Q18

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q19

[ ] 8 DK - GO TO Q19

[ ] 9 RF - GO TO Q19

17. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

GO TO Q19

18. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

19. (Compared with two years ago, how is R's FIRST NAME at:)

Remembering where to find things which have been put in a different place than usual?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Remembering where to find things which had been put in a different place than usual?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q22

[ ] 3 GOTTEN WORSE - GO TO Q21

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q22

[ ] 8 DK - GO TO Q22

[ ] 9 RF - GO TO Q22

20. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q22

21. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

22. (Compared with two years ago, how is R's FIRST NAME at:)

Knowing how to work familiar machines around the house?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Knowing how to work familiar machines around the house?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q25

[ ] 3 GOTTEN WORSE - GO TO Q24

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q25

[ ] 8 DK - GO TO Q25

[ ] 9 RF - GO TO Q25

23. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q25

24. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

25. (Compared with two years ago, how is R's FIRST NAME at:)

Learning to use a new gadget or machine around the house?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Learning to use a new gadget or machine around the house?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q28

[ ] 3 GOTTEN WORSE - GO TO Q27

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q28

[ ] 8 DK - GO TO Q28

[ ] 9 RF - GO TO Q28

26. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q28

27. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

28. (Compared with two years ago, how is R's FIRST NAME at:)

Learning new things in general?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Learning new things in general?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q31

[ ] 3 GOTTEN WORSE - GO TO Q30

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q31

[ ] 8 DK - GO TO Q31

[ ] 9 RF - GO TO Q31

29. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q31

30. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

31. (Compared with two years ago, how is R's FIRST NAME at:)

Following a story in a book or on TV?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Following a story in a book or on TV?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q34

[ ] 3 GOTTEN WORSE - GO TO Q33

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q34

[ ] 8 DK - GO TO Q34

[ ] 9 RF - GO TO Q34

32. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q34

33. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

34. (Compared with two years ago, how is R's FIRST NAME at:)

Making decisions on everyday matters?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Making decisions on everyday matters?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q37

[ ] 3 GOTTEN WORSE - GO TO Q36

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY- GO TO Q37

[ ] 8 DK - GO TO Q37

[ ] 9 RF - GO TO Q37

35. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q37

36. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

37. (Compared with two years ago, how is R's FIRST NAME at:)

Handling money for shopping?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Handling money for shopping?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q40

[ ] 3 GOTTEN WORSE - GO TO Q439

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q40

[ ] 8 DK - GO TO Q40

[ ] 9 RF - GO TO Q40

38. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q40

39. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

40. (Compared with two years ago, how is R's FIRST NAME at:)

Handling financial matters, that is, [his/her] pension or dealing with the bank?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Handling financial matters, for example, a pension or dealing with the bank?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q43

[ ] 3 GOTTEN WORSE - GO TO Q42

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q43

[ ] 8 DK - GO TO Q43

[ ] 9 RF - GO TO Q43

41. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q43

42. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

43. (Compared with two years ago, how is R's FIRST NAME at:)

Handling other everyday arithmetic problems, such as knowing how much food to buy, knowing how long between visits from family or friends? (Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Handling other everyday arithmetic problems, such as knowing how much food to buy, knowing how long between visits from family or friends? (Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q46

[ ] 3 GOTTEN WORSE - GO TO Q45

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q46

[ ] 8 DK - GO TO Q46

[ ] 9 RF - GO TO Q46

44. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q46

45. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

46. (Compared with two years ago, how is R's FIRST NAME at:)

Using [his/her] intelligence to understand what's going on and to reason things through?

(Has this improved, not much changed, or gotten worse?)

(Compared with [when we interviewed [him/her] in R's LAST INTERVIEW MONTH, YEAR/two years ago], how was R's FIRST NAME at:)

Using [his/her] intelligence to understand what was going on and to reason things through?

(Had this improved, not much changed, or gotten worse?)

[ ] 1 IMPROVED

[ ] 2 NOT MUCH CHANGED - GO TO Q49

[ ] 3 GOTTEN WORSE - GO TO Q48

[ ] 4 DOES NOT APPLY; R DOESN'T DO ACTIVITY - GO TO Q49

[ ] 8 DK - GO TO Q49

[ ] 9 RF - GO TO Q49

47. Is it much improved or a bit improved?

[ ] 1 MUCH IMPROVED

[ ] 2 A BIT IMPROVED

[ ] 8 DK

[ ] 9 RF

GO TO Q49

48. Is it much worse or a bit worse?

[ ] 4 A BIT WORSE

[ ] 5 MUCH WORSE

[ ] 8 DK

[ ] 9 RF

49. Now, thinking about some current behaviors, does [he/she] ever get lost in a familiar environment?

Did [he/she] ever get lost in a familiar environment?

[ ] 1 YES

[ ] 5 NO

[ ] 8 DK

[ ] 9 RF

50. Does [he/she] ever wander off and not return by [himself/ herself]?

Did [he/she] ever wander off and not return by [himself/ herself]?

[ ] 1 YES

[ ] 5 NO

[ ] 8 DK

[ ] 9 RF

51. Can [he/she] be left alone for an hour or so?

[Since R's LAST INTERVIEW MONTH, YEAR/In the last two years] could [he/she] be left alone for an hour or so?

[ ] 1 YES

[ ] 5 NO

[ ] 8 DK

[ ] 9 RF

52. Does [he/she] ever see or hear things that are not really there?

Did R's FIRST NAME ever see or hear things that were not really there?

[ ] 1 YES

[ ] 5 NO

[ ] 8 DK

[ ] 9 RF

Personnel and Training Required

The interviewer must be trained to conduct personal interviews with individuals from the general population. The interviewer must be trained and found to be competent (i.e., tested by an expert) at the completion of personal interviews. The interviewer should be trained to prompt respondents further if a "don't know" response is provided.

Equipment Needs

The PhenX Working Group acknowledges these questions can be administered in a computerized or noncomputerized format (i.e., paper-and-pencil instrument). Computer software is necessary to develop computer-assisted instruments. The interviewer will require a laptop computer/handheld computer to administer a computer-assisted questionnaire.

Requirements

Requirement CategoryRequired
Average time of greater than 15 minutes in an unaffected individualNo
Major equipmentNo
Specialized requirements for biospecimen collectionNo
Specialized trainingNo

Mode of Administration

Life Stage:

Senior

Specific Instructions:

The introduction refers to the last month or so of the subject's life. The questions can be administered to the informant before that time, perhaps when there is potential cognitive decline.

Research Domain Information

Release Date:

July 2, 2018

Definition

A screening tool used to determine whether the subject's cognition has improved, stayed the same, or declined over the past two years.

Purpose

This assessment may be used to screen a person for cognitive changes and dementia.

Selection Rationale

The IQCODE is the most commonly used informant-based assessment of cognition.

Language

English, Spanish

Standards

StandardNameIDSource

Process and Review

The Expert Review Panel has yet to review this measure.

Source

Jorm, A. F. & Jacomb, P. A. (1989). The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): Socio-demographic correlates, reliability, validity and some norms. Psychological Medicine, 19(4), 1015-1022.

Health and Retirement Survey, 2016, Section D. Cognition Questions D505 to D557

General References

Jorm, A. F. (2004). The Informant Questionnaire on cognitive decline in the elderly (IQCODE): A review. International Psychogeriatrics, 16(3), 275-293.

Protocol ID:

250501

Variables:

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