Protocol - Behavioral Disturbances

Add to Toolkit

Protocol Name from Source:

Neuropsychiatric Inventory-Questionnaire (NPI-Q)


Publicly available


The NPI-Q is a self-administered questionnaire used by informants (e.g., caregivers) to assess neuropsychiatric symptoms of a patient over the previous month and the effect on the patient and caregiver. Twelve domains and cardinal symptoms of each domain are assessed with yes/no responses. Both severity (a 3-point scale) and distress ratings (a 5-point scale) are recorded for each confirmed symptom. The severity scale applies to the effect on the patient, and the distress scale applies to the effect on the caregiver.


The NPI-Q is proprietary. See the NPI Test website for access to the NPI-Q.


Personnel and Training Required


Equipment Needs



Requirement CategoryRequired
Average time of greater than 15 minutes in an unaffected individualNo
Major equipmentNo
Specialized requirements for biospecimen collectionNo
Specialized trainingNo

Mode of Administration

Life Stage:

Adult, Senior

Specific Instructions:

The NPI-Q is proprietary and copyrighted by Jeffrey L. Cummings, MD. The NPI-Q may be used freely for academic purposes, but there is a fee for commercial use. See this website for details about use of and access to the NPI-Q: [link[npitest.net/terms-of-service.html|http://npitest.net/terms-of-service.html]].

Per NPI-Q background and administration documentation, it is recommended that responses to the NPI-Q be reviewed for completeness by a clinician and for clarifying uncertainties after each administration. The first time a subject completes the NPI-Q, it may be useful to verbally review the instructions. In some instances, it may be necessary to conduct the NPI-Q in part or entirely as an interview.

Current age of the patient (not respondent) is essential to this measure

Research Domain Information

Release Date:

July 2, 2018


This measure is a questionnaire about behaviors associated with agitation that have occurred since an individual began experiencing memory problems.


To provide a brief assessment of neuropsychiatric symptomatology in routine clinical practice settings. The questionnaire assesses the effect on the patient and the distress caused for the respondent (e.g., the caregiver).

Selection Rationale

The NPI-Q has been validated with older adults with dementia and is a commonly used neuropsychiatric questionnaire.





Process and Review

The Expert Review Panel has yet to review this measure.


Neuropsychiatric Inventory-Questionnaire (NPI-Q)

General References

Geda, Y. E., Roberts, R. O., Knopman, D. S., Petersen, R. C., Christianson, T. J., Pankratz, V. S., .. Rocca, W. A. (2008). Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: Population-based study. Archives of General Psychiatry, 65(10),1193-1198.

Kaufer, D. I., Cummings, J. L., Ketchel, P., Smith, V., MacMillan, A., Shelley, T., ... DeKosky, S. T. (2000). Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. Journal of Neuropsychiatry and Clinical Neuroscience, 12(2), 233-239.

Protocol ID:



Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping