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Protocol - Diabetic Peripheral Neuropathy

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Protocol Name from Source:

Feldman, EL, Stevens, MJ, Thomas, PK, Brown, MB, Canal, N & Greene, DA. (1994). A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care, 17(11), 1281-1289.

Availability:

Publicly available

Description:

The Michigan Neuropathy Screening Instrument (MNSI) consists of 15 yes-or-no questions that assess feelings in the legs and feet (distal symmetric polyneuropathy). The MNSI also includes a clinical examination that is not included here.

Protocol:

Please take a few minutes to answer the questions below about the feeling in your legs and feet. Check yes or no based on how you usually feel.

1. Are your legs and/or feet numb?

[ ] Yes

[ ] No

2. Do you ever have any burning pain in your legs and/or feet?

[ ] Yes

[ ] No

3. Are your feet too sensitive to touch?

[ ] Yes

[ ] No

4. Do you get muscle cramps in your legs and/or feet?

[ ] Yes

[ ] No

5. Do you ever have any prickling feelings in your legs or feet?

[ ] Yes

[ ] No

6. Does it hurt when the bed covers touch your skin?

[ ] Yes

[ ] No

7. When you get into the tub or shower, are you able to tell the hot water from the cold water?

[ ] Yes

[ ] No

8. Have you ever had an open sore on your foot?

[ ] Yes

[ ] No

9. Has your doctor ever told you that you have diabetic neuropathy?

[ ] Yes

[ ] No

10. Do you feel weak all over most of the time?

[ ] Yes

[ ] No

11. Are your symptoms worse at night?

[ ] Yes

[ ] No

12. Do your legs hurt when you walk?

[ ] Yes

[ ] No

13. Are you able to sense your feet when you walk?

[ ] Yes

[ ] No

14. Is the skin on your feet so dry that it cracks open?

[ ] Yes

[ ] No

15. Have you ever had an amputation?

[ ] Yes

[ ] No

Total:______/15pts

Scoring Instructions:

Score each positive response as a "1". The greater the score, the greater risk for neuropathy.

Personnel and Training Required

None

Equipment Needs

None

Requirements

Requirement CategoryRequired
Average time of greater than 15 minutes in an unaffected individualNo
Major equipmentNo
Specialized requirements for biospecimen collectionNo
Specialized trainingNo

Mode of Administration

Self-administered

Life Stage:

Adult, Senior

Specific Instructions:

None

Research Domain Information

Release Date:

October 1, 2015

Definition

A questionnaire to determine if a respondent has a history of peripheral neuropathy.

Purpose

Diabetic peripheral neuropathy, also known as distal symmetric polyneuropathy, is a leading complication of both type 1 and type 2 diabetes and is responsible for more than half of all non-traumatic foot amputations in the United States. Incidence of distal symmetric polyneuropathy increases with diabetes duration with up to 50% of those with diabetes having the disease after 25 years (Feldman et al., 1994).

Selection Rationale

The Michigan Neuropathy Screening Instrument (MNSI) was vetted against several other neuropathy protocols and chosen because it is a relatively well validated, widely used instrument.

Language

English

Standards

StandardNameIDSource
Common Data Elements (CDE)Person Diabetic Neuropathy Assessment Description Text3070668CDE Browser
Logical Observation Identifiers Names and Codes (LOINC)Diabetic peripheral neuropathy proto62795-0LOINC

Process and Review

The [link[phenx.org/node/62|Expert Review Panel #1]] reviewed the measures in the Anthropometrics, Diabetes, Physical Activity and Physical Fitness, and Nutrition and Dietary Supplements domains.

Guidance from the ERP includes:

  • No significant changes

Back-compatible: no changes to Data Dictionary

Previous version in Toolkit archive ([link[www.phenxtoolkit.org/index.php?pageLink=browse.archive.protocols&id=140000|link]])

Source

Feldman, EL, Stevens, MJ, Thomas, PK, Brown, MB, Canal, N & Greene, DA. (1994). A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care, 17(11), 1281-1289.

General References

American Diabetes Association (ADA). (2014). Standards of medical care in Diabetes-2014. Diabetes Care, 37 (Suppl. 1), S14 - S80.

Protocol ID:

140401

Variables:

Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
PX140401_Legs_Feet_NumbPX140401010000Are your legs and/or feet numb?4N/A
PX140401_Burning_PainPX140401020000Do you ever have any burning pain in your legs and/or feet?4N/A
PX140401_Feet_Too_Sensitive_To_TouchPX140401030000Are your feet too sensitive to touch?4N/A
PX140401_Muscle_CrampsPX140401040000Do you get muscle cramps in your legs and/or feet?4N/A
PX140401_Prickling_FeelingsPX140401050000Do you ever have any prickling feelings in your legs or feet?4N/A
PX140401_Bed_Covers_HurtPX140401060000Does it hurt when the bed covers touch your skin?4N/A
PX140401_Tell_Hot_Water_From_ColdPX140401070000When you get into the tub or shower, are you able to tell the hot water from the cold water?4N/A
PX140401_Open_SorePX140401080000Have you ever had an open sore on your foot?4N/A
PX140401_Diagnosed_Diabetic_NeuropathyPX140401090000Has your doctor ever told you that you have diabetic neuropathy?4N/A
PX140401_Feel_Weak_All_OverPX140401100000Do you feel weak all over most of the time?4N/A
PX140401_Symptoms_Worse_At_NightPX140401110000Are your symptoms worse at night?4N/A
PX140401_Leg_Hurt_When_WalkPX140401120000Do your legs hurt when you walk?4N/A
PX140401_Sense_Feet_When_WalkingPX140401130000Are you able to sense your feet when you walk?4N/A
PX140401_Skin_Cracks_OpenPX140401140000Is the skin on your feet so dry that it cracks open?4N/A
PX140401_AmputationPX140401150000Have you ever had an amputation?4N/A