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Protocol - Menstrual History

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Protocol Name from Source:

Nurses’ Health Study (NHS), Black Women’s Health Study (BWHS), Study of Women Across the Nation (SWAN)

Availability:

Publicly available

Description:

Females answer questions about the frequency and regularity of her menstrual cycle and whether any irregularities were due to breastfeeding. Females also answer questions about whether their periods have stopped.

Protocol:

1. Since the age of 18, have you ever experienced a time interval of 3 or more months when you did not have a menstrual period? [PROBE: IF "YES": Was this one time only or more than once?]

[ ] 1 No (Skip to question 4)

[ ] 2 Yes One time only

[ ] 3 Yes More than once

[ ] -8 Don’t know (Skip to question 4)

2. Were you breastfeeding at the time?

[ ] 1 No (Skip to question 4)

[ ] 2 Yes

[ ] -8 Don’t know (Skip to question 4)

3. Were you breastfeeding or pregnant every time this happened?

[ ] 1 No

[ ] 2 Yes

[ ] -8 Don’t know

4. During ages 18-22 what was the pattern of your menstrual cycles? (excluding time around pregnancies)

[ ] Regular (within 8 days)

[ ] Usually irregular

[ ] Always irregular

[ ] No periods

5. On average, during the last year, how many days were there in a typical menstrual cycle, that is, from the beginning of bleeding of one menstrual period to the beginning of bleeding of the next period?

[ ] 1 Less than 21 days

[ ] 2 21-25 days

[ ] 3 26-32 days

[ ] 4 33-35 days

[ ] 5 36-90 days

[ ] 6 More than 90 days

[ ] 7 Too variable to say

[ ] -8 Don’t know

6. Have your menstrual periods stopped permanently?

[ ] Yes, no menstrual periods

[ ] Yes, but have periods now due to female hormones (end)

[ ] No (end)

[ ] Not sure (end)

7. How old were you when your periods stopped?

[ ] Less than 35

[ ] 35-39

[ ] 40-44

[ ] 45-49

[ ] 50-54

[ ] 55 or more

Personnel and Training Required

None

Equipment Needs

Pencil and paper

Requirements

Requirement CategoryRequired
Average time of greater than 15 minutes in an unaffected individualNo
Major equipmentNo
Specialized requirements for biospecimen collectionNo
Specialized trainingNo

Mode of Administration

Self-administered

Life Stage:

Adult

Specific Instructions:

The Expert Review Panel recommends that question 4 be framed in the context of when the subject was not taking contraceptives.

Research Domain Information

Release Date:

April 11, 2017

Definition

Questions to determine a female’s menstrual history including disruptions to her menstrual cycle.

Purpose

These questions assess females’ menstrual history.

Selection Rationale

No single protocol was found to cover menstrual history through the life cycle. Therefore the PhenX Reproductive Health Working Group used protocols from three well established sources, the Study of Women’s Health Across the Nation (SWAN), the Nurses’ Health Study (NHS), and the Black Women’s Health Study (BWHS) to address disruptions and the end to menstrual cycles.

Language

English

Standards

StandardNameIDSource
Common Data Elements (CDE)Female Menstrual Cycle History3007481CDE Browser
Logical Observation Identifiers Names and Codes (LOINC)Menstrual hx proto62668-9LOINC

Process and Review

The [link[www.phenx.org/node/110|Expert Review Panel #5]] (ERP 5) reviewed the measures in the Reproductive Health domain.

Guidance from ERP 5 includes:

  • Revised descriptions of the measure

Back-compatible; no changes to Data Dictionary.

Previous version in Toolkit archive ([link[www.phenxtoolkit.org/index.php?pageLink=resources.archive|link]]).

Source

Harvard Medical School. (n.d.). Nurses’ Health Study (NHS), Long Form 1988. Boston, MA: Author. Question number 20 (question 4). National Institute on Aging (NIA), National Institute of Nursing Research (NINR), National Institutes of Health (NIH), et al. (n.d.). Study of Women’s Health Across the Nation (SWAN) Baseline 08-19-04. Question numbers C20 (question 1), C20.1 (question 2), C20.2 (question 3), Question number C11 (question 5).

Slone Epidemiology Center at Boston University (n.d.). Black Women’s Health Study 1995. Boston, MA: Author. Question 21 (questions 6 and 7).

General References

Carroll, J., Saxena, R., & Welt, C. K. (2012). Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome. Journal of Pediatric Endocrinology and Metabolism, 25(5-6), 459-66.

Solomon, C. G., Hu, F. B., Dunaif, A., Rich-Edwards, J., Willett, W. C., Hunter, D. J., . . . Manson, J. E. (2001). Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus. JAMA, 286, 2421-2426.

Solomon, C. G., Hu, F. B., Dunaif, A., Rich-Edwards, J. E., Stampfer, M. J., Willett. W. C., . . . Manson, J. E. (2002). Menstrual cycle irregularity and risk for future cardiovascular disease. Journal of Clinical Endocrinology and Metabolism, 87, 2013-2017.

Carroll, J., Saxena, R., & Welt, C. K. (2012). Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome. Journal of Pediatric Endocrinology and Metabolism, 25(5-6), 459-66.

Protocol ID:

101101

Variables:

Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
PX101101_No_Menstrual_Period_3_More_MonthsPX101101010000Since the age of 18, have you ever experienced a time interval of 3 or more months when you did not have a menstrual period?4Variable Mapping
PX101101_No_Menstrual_Period_BreastfeedingPX101101020000Were you breastfeeding at the time?4N/A
PX101101_No_Menstrual_Period_Breastfeeding_Pregnant_AlwaysPX101101030000Were you breastfeeding or pregnant every time this happened?4N/A
PX101101_Menstrual_Cycle_Pattern_Age_18_22PX101101040000During ages 18-22 what was the pattern of your menstrual cycles? (excluding time around pregnancies)4N/A
PX101101_Menstrual_Cycle_Typical_Days_AveragePX101101050000On average, during the last year, how many days were there in a typical menstrual cycle, that is, from the beginning of bleeding of one menstrual period to the beginning of bleeding of the next period?4Variable Mapping
PX101101_Menstrual_Period_Stop_PermanentlyPX101101060000Have your menstrual periods stopped permanently?4N/A
PX101101_Menstrual_Period_Stop_AgePX101101070000How old were you when your periods stopped?4Variable Mapping