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Protocol - History of Prepubertal Development - Male

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Protocol Name from Source:

Study for Future Families (SFF) and National Longitudinal Survey of Youth (NLSY)

Availability:

Publicly available

Description:

Male participants answer questions about the timing of various maturation milestones.

Protocol:

Think about when the following events happened to you. Was this earlier than most of your friends, around the same time, or later?

1. Your voice changed. Compared to your friends was this:

[ ] 1 Earlier

[ ] 2 About the same time

[ ] 3 Later

[ ] 4 Don’t know

1a. Your age when this occurred: _______

[ ] Don’t know

2. Your penis started increasing in size

[ ] 1 Earlier

[ ] 2 About the same time

[ ] 3 Later

[ ] 4 Don’t know

2a. Your age when this occurred: _______

[ ] Don’t know

3. Your testicles started increasing in size

[ ] 1 Earlier

[ ] 2 About the same time

[ ] 3 Later

[ ] 4 Don’t know

3a. Your age when this occurred: _______

[ ] Don’t know

4. You developed pubic hair

[ ] 1 Earlier

[ ] 2 About the same time

[ ] 3 Later

[ ] 4 Don’t know

4a. Your age when this occurred: _______

[ ] Don’t know

5. People reach puberty at different ages. Signs of puberty for males include physical changes such as developing pubic or facial hair, or the voice cracking or lowering. Would you say these changes:

[ ] 1 Have not yet begun (skip to end)

[ ] 2 Have barely started

[ ] 3 Are definitely underway

[ ] 4 Seem completed

6. How old were you when you entered puberty (that is, when these changes began)?

[ ] Enter age ___

Personnel and Training Required

None

Equipment Needs

Pencil and paper for self-administered questions.

If a computer-assisted instrument is used, computer software may be necessary to develop the instrument. The interviewer will require a laptop computer/handheld computer to administer a computer-assisted questionnaire.

Requirements

Requirement CategoryRequired
Average time of greater than 15 minutes in an unaffected individualNo
Major equipmentNo
Specialized requirements for biospecimen collectionNo
Specialized trainingNo

Mode of Administration

Self-administered

Life Stage:

Adult

Specific Instructions:

In the original protocol (Swan et al., 2003), male questions 1-4 were administered to the partner of a pregnant woman. However, the PhenX Reproductive Health Working Group is recommending this be administered to all men.

The Expert Review Panel recommends that researchers also ask at what age the respondent reached his maximum height (see [link[phenxtoolkitdev.rti.org/index.php?pageLink=browse.protocoldetails&id=100601|History of Prepubertal Development - Female]])

Research Domain Information

Release Date:

April 11, 2017

Definition

Questions to assess how old participants were when they reached puberty.

Purpose

The purpose of these questions is to determine when participants reached puberty. It is important to measure because it is linked to sexual development and maturity.

Selection Rationale

The protocols are from well-established studies with questions that have been used for more than a decade.

Language

English

Standards

StandardNameIDSource
Common Data Elements (CDE)Person Prepuberty Development History3007456CDE Browser
Logical Observation Identifiers Names and Codes (LOINC)Hx prepubertal devel male proto62658-0LOINC

Process and Review

The [link[www.phenx.org/node/110|Expert Review Panel #5]] (ERP 5) reviewed the measures in the Reproductive Health domain.

Guidance from ERP 5 includes:

  • Revised descriptions of the measure

Back-compatible: no changes to Data Dictionary.

Previous version in Toolkit archive ([link[www.phenxtoolkit.org/index.php?pageLink=resources.archive|link]]).

Source

Swan, S. H., Brazil, C., Drobnis, E. Z., Liu, F., Kruse, R. L., Hatch, M., . . . Overstreet, J. W.; Study for Future Families Research Group. Geographic differences in semen quality of fertile U.S. Males. Environmental Health Perspectives, 111(4), 414-420. Questions 1-4. Questions from the Study for Future Families.

National Longitudinal Survey of Youth. U.S. Department of Labor. Center for Human Resource Research, The Ohio State University. NLSY97 Questionnaire and Interviewer’s Reference Manual Round 2. Question YSAQ2-284 (question 5) and question YSAQ2-285 (question 6).

General References

August, G. P., Grumbach, M. M., & Kaplan, S. L. (1972). Hormonal changes in puberty. 3. Correlation of plasma testosterone, LH, FSH, testicular size, and bone age with male pubertal development. Journal of Clinical Endocrinology and Metabolism, 34(2), 319-326.

Burr, I. M., Sizonenko, P. C., Kaplan, S. L., & Grumbach, M. M. (1970). Hormonal changes in puberty. I. Correlation of serum luteinizing hormone and follicle stimulating hormone with stages of puberty, testicular size, and bone age in normal boys Pediatric Research, 4(1), 25-35.

MacLaughlin, D. T., & Donahoe, P. K. (2004). Sex determination and differentiation. New England Journal of Medicine, 350(4), 367-378.

Marshall, W., & Tanner, J. M. (1970). Variations in the pattern of pubertal changes in boys. Archives of Disease in Childhood, 45, 13-23.

Raivio, T., Falardeau, J., Dwyer, A., Quinton, R., Hayes, F. J., Hughes, V.A., . . . Pitteloud, N. (2007). Reversal of idiopathic hypogonadotropic hypogonadism. New England Journal of Medicine, 357(9), 863-873.

Protocol ID:

100602

Variables:

Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
PX100602_Voice_Changed_Peer_ComparisonPX100602010100Think about when the following events happened to you. Was this earlier than most of your friends, around the same time, or later? Your voice changed. Compared to your friends was this:4N/A
PX100602_Voice_Changed_AgePX100602010200What is your age when your voice changed?4N/A
PX100602_Voice_Changed_Age_CodedPX100602010201What is your age when your voice changed?4N/A
PX100602_Penis_Size_Increased_Peer_ComparisonPX100602020100Think about when the following events happened to you. Was this earlier than most of your friends, around the same time, or later? Your penis started increasing in size. Compared to your friends was this:4N/A
PX100602_Penis_Size_Increased_AgePX100602020200What is your age when your penis started increasing in size?4N/A
PX100602_Penis_Size_Increased_Age_CodedPX100602020201What is your age when your penis started increasing in size?4N/A
PX100602_Testicles_Size_Increased_Peer_ComparisonPX100602030100Think about when the following events happened to you. Was this earlier than most of your friends, around the same time, or later? Your testicles started increasing in size. Compared to your friends was this:4N/A
PX100602_Testicles_Size_Increased_AgePX100602030200What is your age when your testicles started increasing in size?4N/A
PX100602_Testicles_Size_Increased_Age_CodedPX100602030201What is your age when your testicles started increasing in size?4N/A
PX100602_Developed_Pubic_Hair_Peer_ComparisonPX100602040100Think about when the following events happened to you. Was this earlier than most of your friends, around the same time, or later? You developed pubic hair. Compared to your friends was this:4N/A
PX100602_Developed_Pubic_Hair_AgePX100602040200What is your age when you developed pubic hair?4N/A
PX100602_Developed_Pubic_Hair_Age_CodedPX100602040201What is your age when you developed pubic hair?4N/A
PX100602_Puberty_ReachPX100602050000People reach puberty at different ages. Signs of puberty for males include physical changes such as developing pubic or facial hair, or the voice cracking or lowering. Would you say these changes:4N/A
PX100602_Puberty_Enter_Began_First_AgePX100602060000How old were you when you entered puberty (that is, when these changes began)?4N/A